Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.44 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.44 |
| ▸ | BCL9 | O00512 | 5/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13901490 | 0.90 | JAK2 (0.44) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL12953255 | 0.90 | CHEK1 (0.48) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL13305009 | 0.90 | USP30 (0.45) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL14050909 | 0.86 | CHEK1 (0.42) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL13305685 | 0.85 | MAP3K12 (0.43) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL14418821 | 0.82 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13901233 | 0.80 | JAK2 (0.46) | TRPC3TRPC7BCL9CTNNB1JAK2 | |
| SCHEMBL13305058 | 0.79 | TRPC3 (0.57) | TRPC3TRPC7PDE4BSMN1; SMN2CYP2C19 | |
| SCHEMBL13993128 | 0.79 | TRPC3 (0.49) | TRPC3TRPC7USP30SMN1; SMN2CYP2C19 | |
| SCHEMBL13901487 | 0.79 | TRPC3 (0.49) | TRPC3TRPC7JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |