Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097701 | 0.88 | ABL1 (0.48) | ABL1FGFR1SRCMTNR1AMTNR1B | |
| SCHEMBL14097711 | 0.83 | ABL1 (0.49) | ABL1FGFR1SRCMTNR1AMTNR1B | |
| SCHEMBL14097679 | 0.76 | ABL1 (0.59) | ABL1GAAKDM4EALDH1A1PIK3CA | |
| SCHEMBL14097683 | 0.71 | ABL1 (0.52) | ABL1 | |
| SCHEMBL14097686 | 0.69 | ABL1 (0.40) | ABL1FGFR1SRCMAPK1PIK3CA | |
| SCHEMBL14097694 | 0.69 | ABL1 (0.52) | ABL1 | |
| SCHEMBL14395390 | 0.69 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097684 | 0.68 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097693 | 0.68 | ABL1 (0.43) | ABL1GSK3BKMT2A | |
| SCHEMBL14097708 | 0.68 | ABL1 (0.48) | ABL1FGFR1SRCRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341769-B1 | BACTERIAL GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2007-10-17 | — | — | EP | disclosed |