Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093586 | 0.90 | MAPT (0.50) | NPC1MEN1KMT2ARAB9AAHR | |
| SCHEMBL2091863 | 0.89 | MAPT (0.47) | TACR3CYP3A4NPC1MEN1KMT2A | |
| SCHEMBL2093496 | 0.89 | NPC1 (0.50) | TACR3CYP3A4RUVBL1PTGESNPC1 | |
| SCHEMBL2093725 | 0.89 | TACR3 (0.44) | TACR3CYP3A4RUVBL1PTGESNPC1 | |
| SCHEMBL2092860 | 0.88 | KDR (0.48) | TACR3CYP3A4RUVBL1NPC1MEN1 | |
| SCHEMBL2094162 | 0.87 | RAB9A (0.52) | NPC1MEN1KMT2ARAB9APOLB | |
| SCHEMBL2091845 | 0.86 | NPC1 (0.44) | TACR3CYP3A4RUVBL1PTGESNPC1 | |
| SCHEMBL2092680 | 0.86 | MEN1 (0.51) | MEN1KMT2ARAB9APOLBGAA | |
| SCHEMBL2093163 | 0.86 | HDAC8 (0.46) | TACR3NPC1MEN1KMT2ARAB9A | |
| SCHEMBL2090594 | 0.84 | RAB9A (0.58) | NPC1MEN1KMT2ARAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007112093-A2 | BENZIMIDAZOLYL-PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-10-04 | — | — | WO | disclosed |