Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.52 |
| ▸ | PI4KA | P42356 | 12/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14397009 | 0.91 | PIK3CD (0.64) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14396839 | 0.89 | PIK3CD (0.51) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14396768 | 0.89 | PIK3CD (0.63) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14397011 | 0.87 | PIK3CD (0.52) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14396776 | 0.86 | PIK3CD (0.52) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14396831 | 0.85 | PIK3CD (0.61) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14396840 | 0.84 | PIK3CD (0.47) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14397004 | 0.84 | PIK3CA (0.46) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL14396825 | 0.82 | CSF1R (0.49) | NPC1MAPTRAB9AFGFR1FGFR2 | |
| SCHEMBL2676357 | 0.80 | SYK (0.38) | PIK3CANPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |