Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14396846 | 0.95 | CSF1R (0.49) | CSF1RTTKPDGFRBPDGFRAKIT | |
| SCHEMBL14396651 | 0.93 | CSF1R (0.47) | CSF1RTTKPDGFRBPDGFRAKIT | |
| SCHEMBL14396851 | 0.93 | CSF1R (0.47) | CSF1RTTKPDGFRBPDGFRAKIT | |
| SCHEMBL14396483 | 0.90 | CSF1R (0.51) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL2677824 | 0.90 | CSF1R (0.55) | CSF1RTTKPDGFRBPDGFRAKIT | |
| SCHEMBL14396825 | 0.89 | CSF1R (0.49) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396855 | 0.89 | CSF1R (0.49) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396824 | 0.88 | CSF1R (0.51) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14397057 | 0.88 | CSF1R (0.52) | CSF1RPDGFRBPDGFRAKITFLT3 | |
| SCHEMBL14396853 | 0.87 | CSF1R (0.44) | CSF1RPDGFRBPDGFRAKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | disclosed |