SCHEMBL14397196

SCHEMBL14397196

CNC(=O)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(C)c4)ncnc32)C(O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.83
ADORA3 P0DMS8 3/20 0.83
MAPK1 P28482 2/20 0.83
BLM P54132 2/20 0.83
PMP22 Q01453 2/20 0.83
TSHR P16473 2/20 0.83
NFKB1 P19838 2/20 0.83
CYP1A2 P05177 1/20 0.83
MAPT P10636 1/20 0.83
LMNA P02545 1/20 0.83
CYP2D6 P10635 1/20 0.83
PKM P14618 1/20 0.83
ABCG2 Q9UNQ0 1/20 0.83
HTR2C P28335 1/20 0.83
ADORA2A P29274 1/20 0.83
ADORA2B P29275 1/20 0.83
ADORA1 P30542 1/20 0.83
HTR2B P41595 1/20 0.83
RXFP1 Q9HBX9 1/20 0.83
ALDH1A1 P00352 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13382550 1.00 CYP3A4 (0.83) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL29634441 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL20905217 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL10089200 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL29384499 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL465039 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL448115 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL10089244 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL8922766 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22
Ib-Meca SCHEMBL29572081 0.91 ADORA3 (1.00) CYP3A4ADORA3MAPK1BLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007120972-A2 METHOD TO TREAT SICKLE CELL DISEASE UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2007-10-25 WO disclosed