Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811631 | 0.93 | PTGES (0.53) | PTGESMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL20702176 | 0.91 | PTGES (0.54) | PTGESMAPTCYP3A4ALDH1A1TSHR | |
| SCHEMBL1440337 | 0.89 | PTGES (0.56) | PTGESMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL1440663 | 0.88 | PTGES (0.54) | PTGESMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL1440559 | 0.86 | PTGES (0.65) | PTGESMAPTCYP3A4ALDH1A1TSHR | |
| SCHEMBL1440613 | 0.84 | PTGES (0.59) | PTGESMAPT | |
| SCHEMBL1440225 | 0.83 | PTGES (0.74) | PTGESALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL1440697 | 0.83 | PTGES (0.58) | PTGESMAPT | |
| SCHEMBL1440322 | 0.81 | PTGES (0.52) | PTGESMAPTHPGDUSP2LMNA | |
| SCHEMBL1439832 | 0.81 | PTGES (0.55) | PTGESMAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023812-A1 | MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES1) INHIBITORS | NOVASAID AB (SE) | 2011-03-03 | — | — | WO | disclosed |