Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14404177 | 0.89 | MAPT (0.46) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL14399940 | 0.86 | KDM1A (0.57) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL14404048 | 0.86 | SMN1; SMN2 (0.54) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL14404141 | 0.84 | RAB9A (0.57) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL14399899 | 0.80 | MAPT (0.49) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL14404038 | 0.79 | MAPT (0.38) | MAPTALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL27178196 | 0.77 | MAPT (0.80) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL27178203 | 0.77 | MAPT (0.80) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL30826067 | 0.77 | MAPT (0.80) | MAPTALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL14404098 | 0.76 | MAPT (0.37) | MAPTALDH1A1KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007116314-A1 | N-PHENYL-1,1,1-TRIFLUOROMETHANESULFONAMIDE HYDRAZONE DERIVATIVE COMPOUNDS AND THEIR USAGE IN CONTROLLING PARASITES | SCHERING-PLOUGH LTD. (US) | 2007-10-18 | — | — | WO | disclosed |