Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.46 |
| ▸ | DNMT3L | Q9UJW3 | 2/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10269739 | 0.89 | MAPKAPK2 (0.58) | ROCK1MAPKAPK2ULK1JAK2JAK1 | |
| SCHEMBL10269232 | 0.88 | ROCK1 (0.57) | ROCK1MAPKAPK2ULK1JAK2ROCK2 | |
| SCHEMBL10269234 | 0.88 | MAPKAPK2 (0.49) | ROCK1MAPKAPK2ULK1DNMT1EHMT1 | |
| SCHEMBL10269411 | 0.80 | ROCK1 (0.55) | ROCK1MAPKAPK2ULK1DNMT1EHMT1 | |
| SCHEMBL10214706 | 0.79 | MAPKAPK2 (0.64) | ROCK1MAPKAPK2ULK1JAK2JAK1 | |
| SCHEMBL10269340 | 0.77 | MAPKAPK2 (0.60) | ROCK1MAPKAPK2JAK2JAK1LRRK2 | |
| SCHEMBL10269198 | 0.77 | FLT3 (0.60) | ROCK1MAPKAPK2ULK1LRRK2 | |
| SCHEMBL758447 | 0.77 | ROCK1 (0.56) | ROCK1MAPKAPK2 | |
| SCHEMBL10214704 | 0.76 | MAPKAPK2 (0.64) | ROCK1MAPKAPK2LRRK2 | |
| SCHEMBL10269613 | 0.76 | MAPKAPK2 (0.54) | ROCK1MAPKAPK2ULK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |