Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.52 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14404257 | 0.88 | ROCK1 (0.53) | ROCK1MAPKAPK2JAK2ROCK2ULK1 | |
| SCHEMBL10269739 | 0.87 | MAPKAPK2 (0.58) | ROCK1MAPKAPK2CDK7JAK2ITK | |
| SCHEMBL10269234 | 0.86 | MAPKAPK2 (0.49) | ROCK1MAPKAPK2JAK2ROCK2NPC1 | |
| SCHEMBL10268598 | 0.81 | MAPKAPK2 (0.71) | ROCK1MAPKAPK2ROCK2PRKACADYRK1A | |
| SCHEMBL758654 | 0.80 | CDK7 (0.58) | ROCK1CDK7CDC7DAPK3JAK2 | |
| SCHEMBL10214706 | 0.76 | MAPKAPK2 (0.64) | ROCK1MAPKAPK2JAK2ROCK2ITK | |
| SCHEMBL2527438 | 0.76 | FLT3 (0.62) | CDK7CDC7DAPK3JAK2ROCK2 | |
| SCHEMBL10269411 | 0.75 | ROCK1 (0.55) | ROCK1MAPKAPK2JAK2CDK2FLT3 | |
| SCHEMBL10269154 | 0.75 | MAPKAPK2 (0.77) | ROCK1MAPKAPK2KDRITK | |
| SCHEMBL10269200 | 0.75 | ROCK1 (0.56) | ROCK1MAPKAPK2ROCK2CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | ROCK1 2438/4885MAPKAPK2 1905/4885CDK7 693/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | ROCK1 2438/4885MAPKAPK2 1905/4885CDK7 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.