Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.32 |
| ▸ | PI4KA | P42356 | 5/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24714020 | 0.82 | PI4KA (0.36) | MAP4K4PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15741407 | 0.79 | — | — | |
| SCHEMBL20088858 | 0.77 | CA2 (0.38) | CA2CHKARPS6KB1XDH | |
| SCHEMBL12264312 | 0.72 | CA2 (0.44) | CA2CHKAXDHMAP4K4PI4KA | |
| SCHEMBL179361 | 0.70 | CA2 (0.35) | CA2CHKAXDHPI4KAPI4K2B | |
| SCHEMBL793968 | 0.68 | — | — | |
| SCHEMBL18809713 | 0.68 | — | — | |
| SCHEMBL16992858 | 0.68 | HTT (0.49) | NOS3NOS2LMNA | |
| SCHEMBL16783456 | 0.67 | SGK1 (0.38) | CA2CHKAXDHPI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL16992973 | 0.67 | HTT (0.47) | NOS3NOS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473049-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011029046-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |