Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15270205 | 0.94 | EPHX1 (0.52) | EPHX1TSHRTDP1SIGMAR1NPC1 | |
| SCHEMBL4424894 | 0.89 | — | — | |
| SCHEMBL8078349 | 0.88 | TSHR (0.47) | EPHX1TSHRTDP1SIGMAR1HPGD | |
| SCHEMBL6255210 | 0.85 | SIGMAR1 (0.55) | EPHX1TSHRSIGMAR1 | |
| SCHEMBL16570238 | 0.85 | SIGMAR1 (0.55) | EPHX1TSHRSIGMAR1 | |
| SCHEMBL7776480 | 0.83 | EPHX1 (0.75) | EPHX1SIGMAR1NPC1RAB9AL3MBTL1 | |
| SCHEMBL22461913 | 0.81 | EPHX1 (0.45) | EPHX1TSHRTDP1SIGMAR1HPGD | |
| SCHEMBL6062059 | 0.81 | EPHX1 (0.61) | EPHX1SIGMAR1NPC1RAB9AL3MBTL1 | |
| SCHEMBL8393790 | 0.81 | EPHX1 (0.61) | EPHX1SIGMAR1NPC1RAB9AL3MBTL1 | |
| SCHEMBL8391133 | 0.81 | EPHX1 (0.61) | EPHX1SIGMAR1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473049-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011029046-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |