Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 12/20 | 0.73 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.53 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.53 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.53 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248707 | 0.90 | EPHX2 (0.75) | EPHX2MEN1KMT2A | |
| SCHEMBL14409364 | 0.86 | EPHX2 (0.69) | EPHX2ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL14409455 | 0.85 | EPHX2 (0.67) | EPHX2ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL7323389 | 0.84 | ORAI1 (0.66) | EPHX2ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL14409451 | 0.83 | EPHX2 (0.68) | EPHX2 | |
| SCHEMBL4247416 | 0.82 | EPHX2 (0.79) | EPHX2ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL4246198 | 0.82 | EPHX2 (0.77) | EPHX2ALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL14409363 | 0.82 | EPHX2 (0.62) | EPHX2ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL4254875 | 0.82 | EPHX2 (1.00) | EPHX2ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL13702334 | 0.80 | EPHX2 (0.74) | EPHX2ORAI1TRPC1TRPC3STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406892-B1 | PHENYL PYRAZOLE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-09-05 | — | — | EP | disclosed |