Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HGF | P14210 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104694 | 0.87 | MET (0.55) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL2285261 | 0.73 | MET (0.58) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL3101384 | 0.73 | MET (0.53) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL3107124 | 0.72 | MET (0.63) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL3110874 | 0.72 | LRRK2 (0.41) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL2281471 | 0.69 | MET (0.50) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL3111401 | 0.68 | MET (0.66) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL2288757 | 0.67 | MET (0.58) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL13116045 | 0.66 | MET (0.58) | METJAK2EGFRHGFFLT1 | |
| SCHEMBL12409582 | 0.66 | MET (0.45) | METBDKRB1JAK2EGFRHGF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103308-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-09-13 | — | — | WO | disclosed |