SCHEMBL14411925

SCHEMBL14411925

COC(=O)[C@H](C)NC(=O)C(C)(C)Br

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA14 Q9ULX7 2/20 0.42
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
BIRC2 Q13490 1/20 0.40
TSHR P16473 4/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
RECQL P46063 2/20 0.39
CA12 O43570 1/20 0.39
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
MAPK1 P28482 1/20 0.37
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2555385 0.84 MAPT (0.39) CA14MAPTL3MBTL1MEN1KMT2A
SCHEMBL17130272 0.83 CA14 (0.45) CA14MAPTL3MBTL1BIRC2TSHR
SCHEMBL10223236 0.83 CA14 (0.45) CA14MAPTL3MBTL1BIRC2TSHR
SCHEMBL17130270 0.83 CA14 (0.45) CA14MAPTL3MBTL1BIRC2TSHR
SCHEMBL21638018 0.83 CA14 (0.45) CA14MAPTL3MBTL1BIRC2TSHR
SCHEMBL23894861 0.83 CA14 (0.45) CA14MAPTL3MBTL1BIRC2TSHR
SCHEMBL22092480 0.78 SMN1; SMN2 (0.38) MAPTTSHRMEN1KMT2AALDH1A1
SCHEMBL8944922 0.77 CA14 (0.43) CA14MAPTL3MBTL1TSHRMEN1
SCHEMBL943623 0.75 SIGMAR1 (0.38) MAPTL3MBTL1TSHRMEN1KMT2A
SCHEMBL16299702 0.75 CA14 (0.38) CA14MAPTL3MBTL1BIRC2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070219330-A1 Amide initiators WARWICK EFFECT POLYMERS LIMITED (GB) 2007-09-20 US disclosed
US-20070219330-A1 Amide initiators WARWICK EFFECT POLYMERS LIMITED (GB) 2007-09-20 US disclosed