Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.61 |
| ▸ | RIPK3 | Q9Y572 | 5/20 | 0.61 |
| ▸ | AXL | P30530 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MERTK | Q12866 | 3/20 | 0.55 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13368484 | 0.86 | MET (0.64) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL1161171 | 0.84 | MET (0.66) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL12561530 | 0.83 | MET (0.62) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL2425285 | 0.81 | MET (0.60) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL13212979 | 0.78 | AXL (0.60) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL19377723 | 0.78 | MET (0.56) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL29626156 | 0.78 | MET (0.56) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL18256977 | 0.78 | MET (0.57) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL25648992 | 0.76 | MET (0.56) | METRIPK3AXLCYP3A4CYP2C9 | |
| SCHEMBL15948862 | 0.76 | MET (0.50) | METRIPK3AXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103308-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-09-13 | — | — | WO | disclosed |