⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394020 | 0.74 | — | — | |
| SCHEMBL16378643 | 0.72 | — | — | |
| SCHEMBL7750282 | 0.67 | — | — | |
| SCHEMBL1568155 | 0.67 | THRB (0.57) | — | |
| SCHEMBL14763948 | 0.67 | THRB (1.00) | — | |
| SCHEMBL18928 | 0.67 | THRB (1.00) | — | |
| SCHEMBL18787584 | 0.67 | THRB (0.47) | — | |
| SCHEMBL7039046 | 0.65 | THRB (0.44) | — | |
| SCHEMBL131012 | 0.65 | THRB (0.44) | — | |
| SCHEMBL1074130 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250019732-A1 | METHOD FOR CHEMICAL-BIOLOGICAL CASCADE SYNTHESIS OF L-PHOSPHINOTHRICIN AND MUTANTS THEREFOR | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2025-01-16 | — | — | US | claimed |
| US-20250019732-A1 | METHOD FOR CHEMICAL-BIOLOGICAL CASCADE SYNTHESIS OF L-PHOSPHINOTHRICIN AND MUTANTS THEREFOR | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2025-01-16 | — | — | US | disclosed |
| US-20250019732-A1 | METHOD FOR CHEMICAL-BIOLOGICAL CASCADE SYNTHESIS OF L-PHOSPHINOTHRICIN AND MUTANTS THEREFOR | ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) | 2025-01-16 | — | — | US | disclosed |
| CN-116940575-A | Thienopyrimidinedione compounds and application thereof | 深圳市康哲药业有限公司 | 2023-10-24 | — | — | CN | disclosed |
| WO-2022179469-A1 | THIENOPYRIMIDINEDIONE COMPOUNDS AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2022-09-01 | — | — | WO | disclosed |
| US-9988388-B2 | Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof | UNIVERSITE DE BOURGOGNE (FR) | 2018-06-05 | — | — | US | disclosed |
| US-9981967-B2 | Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof | UNIVERSITE DE BOURGOGNE (FR) | 2018-05-29 | — | — | US | disclosed |
| EP-2922830-B1 | SYNTHESIS OF IMIDAZO(1,2-A)PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF | UNIV BOURGOGNE (FR) | 2018-05-16 | — | — | EP | disclosed |
| EP-2438056-B1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS LLC (US) | 2017-12-20 | — | — | EP | disclosed |
| US-20160222018-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C- FUNCTIONALIZED DERIVATIVES THEREOF | UNIVERSITE DE BOURGOGNE (FR) | 2016-08-04 | — | — | US | disclosed |
| EP-0570574-A1 | BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACID COMPLEXES, THEIR PREPARATION, CONJUGATES AND RADIOPHARMACEUTICALS | THE DOW CHEMICAL COMPANY (US) | 1993-11-24 | — | — | EP | disclosed |
| EP-0570575-A1 | BICYCLOAZAMACROCYCLOPHOSPHONIC ACID, CONJUGATES, CONTRAST AGENTS AND PREPARATION | THE DOW CHEMICAL COMPANY (US) | 1993-11-24 | — | — | EP | disclosed |
| CN-1074447-A | Bicyclopolyazamacrocacidshosphonic acidshosphonic, its title complex and conjugate and their preparation method thereof as contrast medium | DOW CHEMICAL CO (US) | 1993-07-21 | — | — | CN | disclosed |
| WO-1993011802-A1 | BICYCLOAZAMACROCYCLOPHOSPHONIC ACID, CONJUGATES, CONTRAST AGENTS AND PREPARATION | THE DOW CHEMICAL COMPANY (US) | 1993-06-24 | — | — | WO | disclosed |
| WO-1993011801-A1 | BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACID COMPLEXES, THEIR PREPARATION, CONJUGATES AND RADIOPHARMACEUTICALS | THE DOW CHEMICAL COMPANY (US) | 1993-06-24 | — | — | WO | disclosed |
| EP-0455380-A2 | Tetra-aza macrocycles; processes for their preparation, and their use in magnetic resonance imaging | CELLTECH THERAPEUTICS LIMITED (GB) | 1991-11-06 | — | — | EP | disclosed |
| WO-1991016081-A1 | TETRA-AZA MACROCYCLES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN MAGNETIC RESONANCE IMAGING | CELLTECH LIMITED (GB) | 1991-10-31 | — | — | WO | disclosed |
| WO-1990009388-A1 | TETRA-AZA MACROCYCLES AND PROCESSES FOR THEIR PREPARATION | CELLTECH LIMITED (GB) | 1990-08-23 | — | — | WO | disclosed |
| EP-0382582-A1 | Tetra-aza macrocyles and processes for their preparation | CELLTECH THERAPEUTICS LIMITED (GB) | 1990-08-16 | — | — | EP | disclosed |
| US-4743687-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1988-05-10 | — | — | US | disclosed |