Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905916 | 0.82 | ADORA1 (0.77) | ADORA2AADORA1ADORA2BMAPTRXFP1 | |
| SCHEMBL14413494 | 0.82 | RIPK2 (0.56) | ADORA2AADORA1ADORA2BPIK3CGMAPT | |
| SCHEMBL1892740 | 0.81 | ADORA2A (0.59) | ADORA2AADORA1HRH2HRH3HPGD | |
| SCHEMBL10367722 | 0.80 | DHPS (0.62) | ADORA2AADORA1ADORA2BMAPTDPP4 | |
| SCHEMBL7777497 | 0.80 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BPIK3CGMAPT | |
| SCHEMBL17544648 | 0.78 | PIK3CG (0.64) | ADORA2AADORA1ADORA2BPIK3CGMAPT | |
| SCHEMBL27631918 | 0.78 | PIK3CG (0.64) | ADORA2AADORA1ADORA2BPIK3CGMAPT | |
| SCHEMBL26708031 | 0.77 | KDM4E (0.61) | ADORA2AADORA1ADORA2BHPGDHTT | |
| SCHEMBL14413002 | 0.77 | DYRK1A (0.51) | ADORA2AADORA1KDM4E | |
| SCHEMBL2321715 | 0.77 | ADORA2A (0.81) | ADORA2AADORA1ADORA2BPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098835-A1 | AMINO PYRYMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-09-07 | — | — | WO | disclosed |