Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.74 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.66 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.65 |
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772943 | 0.93 | EDNRA (0.79) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL14414624 | 0.92 | EDNRA (0.75) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL5534075 | 0.86 | AGTR1 (0.66) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL4773774 | 0.85 | EDNRA (1.00) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL6540813 | 0.85 | EDNRA (0.80) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL25084430 | 0.84 | AGTR1 (0.71) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL30844578 | 0.84 | AGTR1 (0.71) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL6539114 | 0.84 | AGTR1 (0.80) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL6540548 | 0.83 | AGTR1 (0.81) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL6539684 | 0.83 | EDNRA (0.89) | EDNRAAGTR1AGTR2ACHELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109456-A2 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2007-09-27 | — | — | WO | disclosed |