AGTR1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2773	0.51	18/20
SCHEMBL2423	0.55	16/20
SCHEMBL3085	0.55	16/20
SCHEMBL2795	0.54	16/20
SCHEMBL2796	0.54	16/20
SCHEMBL3048	0.52	16/20
SCHEMBL3117	0.52	16/20
SCHEMBL3011	0.51	16/20
SCHEMBL3185	0.51	16/20
SCHEMBL3248	0.56	15/20
SCHEMBL3249	0.56	15/20
SCHEMBL2529	0.53	15/20
SCHEMBL2803	0.61	14/20
SCHEMBL2804	0.61	14/20
SCHEMBL2913	0.53	14/20
Olmesartan Medoxomil (SCHEMBL16403)	1.00	13/20
SCHEMBL2251	0.73	13/20
SCHEMBL2252	0.73	13/20
SCHEMBL2373	0.73	13/20
SCHEMBL2844	0.72	13/20

Clinical trials — most relevant to AGTR1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Olmesartan on Angiotensin(1-7) Levels and Vascular Functions in Diabetes and Hypertension	PHASE4	COMPLETED
Valsartan for Suppression of Plaque Volume and Restenosis After Drug-Eluting Stent	PHASE4	COMPLETED
Blood Pressure Regulation - Role of Potassium	PHASE4	COMPLETED
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension	PHASE4	COMPLETED
Telmisartan for Treatment of COVID-19 Patients	PHASE4	COMPLETED
The Effects of Peroxisome Proliferators Activated Receptor-Gamma (PPAR-γ) Agonists on Certain Biochemical and Inflammatory Markers in Metabolic Syndrome	PHASE4	COMPLETED
Evaluate the Efficacy of Fenofibrate on Microalbuminuria	PHASE4	UNKNOWN
Telmisartan and Losartan in Hypertensive IGT	PHASE4	COMPLETED
Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension	PHASE3	COMPLETED
A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension	PHASE3	COMPLETED
The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function	PHASE3	COMPLETED
The Role of Angiotensin Type I Receptor in the Regulation of Human Coronary Vascular Function	PHASE3	COMPLETED
The Potential of Candesartan to Retard the Progression of Aortic Stenosis	PHASE3	UNKNOWN
Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C	PHASE3	COMPLETED
Efficacy and Safety of Azilsartan in Subjects With Essential Hypertension	PHASE2	COMPLETED
: Vascular Function in Health and Disease	PHASE1	RECRUITING
Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications	PHASE1	UNKNOWN
Expression and Function of the Renin-Angiotensin System in the Esophagus	EARLY_PHASE1	COMPLETED
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome	nan	UNKNOWN
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker	nan	UNKNOWN
Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)	nan	COMPLETED
Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Risk of COVID_19	nan	UNKNOWN
Residual Renal Function Preservation in Peritoneal Dialysis Patients	nan	UNKNOWN
Clinical Study Evaluating the Effect of Losartan	nan	RECRUITING
Renin-Angiotensin System Inhibitors and COVID-19	nan	UNKNOWN
Long Term Effects of Enalapril and Losartan on Genetic Heart Disease	nan	COMPLETED
Non-invasive Haemodynamic Assessment in Hypertension	nan	COMPLETED
Racial Variation in ACE--Genetic and Physiologic Bases	nan	COMPLETED
Effects of Fimasartan on Insulin Secretion in Type 2 Diabetic Patients	nan	COMPLETED
Association of Circulating ACE2 Levels With COVID-19	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AGTR1 binder may also engage these)

Protein	Name	Similarity
P34976	—	1.000	P34976 →
P29089	—	1.000	P29089 →
P79785	—	1.000	P79785 →
P29754	—	1.000	P29754 →
P30555	—	1.000	P30555 →
Q9WV26	—	1.000	Q9WV26 →
P35373	—	1.000	P35373 →
P25104	—	1.000	P25104 →
Q9GLN9	—	1.000	Q9GLN9 →
P32303	—	1.000	P32303 →
O77590	—	1.000	O77590 →
P33396	—	0.999	P33396 →
P29755	—	0.998	P29755 →
O35210	—	0.998	O35210 →
P25095	—	0.997	P25095 →
P43240	—	0.997	P43240 →
P56491	—	0.996	P56491 →
P51676	—	0.995	P51676 →
P56482	—	0.995	P56482 →
P61072	—	0.994	P61072 →
O19024	—	0.994	O19024 →
Q7YS92	—	0.994	Q7YS92 →
Q95ND1	—	0.994	Q95ND1 →
Q28474	—	0.994	Q28474 →
P35374	—	0.993	P35374 →
O97962	—	0.993	O97962 →
O97880	—	0.993	O97880 →
P51683	—	0.993	P51683 →
O97879	—	0.992	O97879 →
P61757	—	0.992	P61757 →