Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14613385 | 0.94 | GSK3B (0.57) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289590 | 0.89 | GSK3B (0.57) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13122026 | 0.89 | GSK3B (0.72) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305560 | 0.82 | GSK3B (0.65) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289369 | 0.82 | GSK3B (0.60) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13122078 | 0.82 | GSK3B (0.75) | GSK3BCDK2CCNE1 | |
| SCHEMBL13122144 | 0.81 | GSK3B (0.71) | GSK3BCDK2CCNE1 | |
| SCHEMBL14043346 | 0.80 | GSK3B (0.53) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL12954066 | 0.79 | GSK3B (0.61) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14301719 | 0.76 | GSK3B (0.54) | GSK3BCHEK1CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225270-A1 | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225270-A1 | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | CDK2, CDKN1A, CDK1 | GSK3B 749/4885CHEK1 58/4885CDK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.