Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KISS1R | Q969F8 | 8/20 | 0.46 |
| ▸ | SENP5 | Q96HI0 | 4/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 4/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14581633 | 0.92 | CDK2 (0.49) | SENP5SENP2SENP1MAPTMEN1 | |
| SCHEMBL14581408 | 0.88 | SENP1 (0.50) | SENP5SENP2SENP1SIRT2SIRT1 | |
| SCHEMBL14613477 | 0.87 | KCNK3 (0.42) | SENP5SENP2SENP1ACKR3GSK3B | |
| SCHEMBL14613482 | 0.86 | GSK3B (0.42) | SENP5SENP2SENP1MEN1KMT2A | |
| SCHEMBL14051030 | 0.86 | MAPT (0.42) | KISS1RSENP5SENP2SENP1MAPT | |
| SCHEMBL14051031 | 0.84 | KCNK3 (0.42) | GSK3B | |
| SCHEMBL14613272 | 0.84 | GSK3B (0.42) | GSK3B | |
| SCHEMBL14581256 | 0.83 | AURKA (0.45) | KISS1RMEN1KMT2AACKR3GSK3B | |
| SCHEMBL13119622 | 0.83 | CDK2 (0.61) | ACKR3GSK3B | |
| SCHEMBL14613333 | 0.83 | EPHB4 (0.45) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225270-A1 | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION | 2007-09-27 | — | — | US | disclosed |
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | SCHERING CORPORATION | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225270-A1 | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | CDK2, CDKN1A, CDK1 | KISS1R 2135/4885SENP5 1206/4885SENP2 2203/4885 |
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | CDK2, CDK5, CDKN1A | KISS1R 2664/4885SENP5 519/4885SENP2 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.