Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | AKT1 | P31749 | 14/20 | 0.49 |
| ▸ | AKT2 | P31751 | 9/20 | 0.49 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14419015 | 0.87 | AKT1 (0.66) | OPRM1OPRL1OPRK1AKT1AKT2 | |
| SCHEMBL14419014 | 0.87 | AKT1 (0.66) | OPRM1OPRL1OPRK1AKT1AKT2 | |
| SCHEMBL12394836 | 0.87 | OPRM1 (0.58) | OPRM1OPRL1OPRK1AKT1AKT2 | |
| SCHEMBL1859464 | 0.80 | OPRL1 (0.86) | OPRM1OPRL1OPRK1CTSS | |
| SCHEMBL13869097 | 0.80 | OPRL1 (0.73) | OPRM1OPRL1OPRK1AKT1AKT2 | |
| SCHEMBL14419058 | 0.79 | AKT1 (0.77) | AKT1AKT2AKT3TDP1RUVBL1 | |
| SCHEMBL181682 | 0.76 | OPRM1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL1860312 | 0.72 | OPRM1 (0.74) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3871435 | 0.71 | OPRL1 (0.68) | OPRM1OPRL1OPRK1 | |
| SCHEMBL1863856 | 0.69 | OPRM1 (0.76) | OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273869-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2007-09-25 | — | — | US | disclosed |