Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 5/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287527 | 0.89 | CCR1 (0.58) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL10287667 | 0.89 | CCR1 (0.54) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL10287959 | 0.89 | CCR1 (0.54) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL10287974 | 0.89 | CCR1 (0.56) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL7210846 | 0.89 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ALDH1A1 | |
| SCHEMBL7210849 | 0.89 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ALDH1A1 | |
| SCHEMBL10287550 | 0.88 | CCR1 (0.51) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL12121529 | 0.88 | CCR1 (0.56) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL12121687 | 0.88 | CCR1 (0.53) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL10287960 | 0.87 | CCR1 (0.54) | CCR1CHRM2CCR5TBXA2RHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |