Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14579586 | 0.89 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10287604 | 0.89 | CCR1 (0.59) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL12121530 | 0.88 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL14419957 | 0.88 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL13824238 | 0.88 | CCR1 (0.55) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10288241 | 0.87 | CCR1 (0.69) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10287608 | 0.87 | CCR1 (0.61) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL14579622 | 0.87 | CCR1 (0.61) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10288253 | 0.86 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10288259 | 0.86 | CCR1 (0.58) | CCR1CHRM2CCR5HRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |