Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655909 | 1.00 | CCR1 (0.66) | CCR1CHRM2CCR5LMNATSHR | |
| SCHEMBL655908 | 1.00 | CCR1 (0.66) | CCR1CHRM2CCR5LMNATSHR | |
| SCHEMBL18633828 | 0.86 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL15478419 | 0.86 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1TBXA2R | |
| SCHEMBL656127 | 0.86 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1TBXA2R | |
| SCHEMBL655139 | 0.86 | CCR1 (0.63) | CCR1CHRM2CCR5HTR2AHRH1 | |
| SCHEMBL655115 | 0.86 | CCR1 (0.63) | CCR1CHRM2CCR5HTR2AHRH1 | |
| SCHEMBL15478327 | 0.86 | CCR1 (0.70) | CCR1CHRM2CCR5LMNATSHR | |
| SCHEMBL3836897 | 0.86 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1TBXA2R | |
| SCHEMBL3836896 | 0.86 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |