Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656127 | 0.93 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL15478419 | 0.93 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL3836896 | 0.86 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL3836897 | 0.86 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL655908 | 0.86 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14420172 | 0.86 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL655909 | 0.86 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656144 | 0.85 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656143 | 0.85 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL656470 | 0.83 | CCR1 (0.65) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1688418-B1 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARM INC (US) | 2017-03-15 | — | — | EP | disclosed |