Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 6/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655011 | 1.00 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1TBXA2R | |
| SCHEMBL655010 | 1.00 | CCR1 (0.57) | CCR1CHRM2CCR5HRH1TBXA2R | |
| SCHEMBL654107 | 0.87 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL654106 | 0.87 | CCR1 (0.75) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL13824233 | 0.85 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10288257 | 0.83 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL12121902 | 0.82 | CCR1 (0.62) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL14420165 | 0.82 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL15478407 | 0.82 | CCR1 (0.76) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL10288261 | 0.81 | CCR1 (0.59) | CCR1CHRM2CCR5HRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |