Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211997 | 0.93 | CCR1 (0.47) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL7212000 | 0.93 | CCR1 (0.47) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL7212913 | 0.92 | CCR1 (0.54) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL7212910 | 0.92 | CCR1 (0.54) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL10287856 | 0.90 | CCR1 (0.46) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL7207268 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL7207266 | 0.88 | CCR1 (0.49) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL13824388 | 0.88 | CCR1 (0.46) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL10287855 | 0.88 | CCR1 (0.46) | CCR1CHRM2CCR5DRD2DRD4 | |
| SCHEMBL14419953 | 0.86 | CCR1 (0.56) | CCR1CHRM2CCR5DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |