Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207268 | 1.00 | CCR1 (0.49) | CCR1CHRM2CCR5TBXA2RMAOB | |
| SCHEMBL7211997 | 0.89 | CCR1 (0.47) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL7212000 | 0.89 | CCR1 (0.47) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL14420183 | 0.88 | CCR1 (0.47) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL7210838 | 0.88 | HRH3 (0.46) | CCR1CHRM2CCR5TBXA2RMAOB | |
| SCHEMBL7210843 | 0.88 | HRH3 (0.46) | CCR1CHRM2CCR5TBXA2RMAOB | |
| SCHEMBL13824388 | 0.88 | CCR1 (0.46) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL10287855 | 0.88 | CCR1 (0.46) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL7212913 | 0.87 | CCR1 (0.54) | CCR1CHRM2CCR5KDM4E | |
| SCHEMBL7212910 | 0.87 | CCR1 (0.54) | CCR1CHRM2CCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| US-6613905-B1 | Treating or preventing a disease associated with aberrant leukocyte recruitment and/or activation | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-02 | — | — | US | disclosed |