Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 4/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617505 | 0.89 | CCR1 (0.57) | CCR1CHRM2CCR5TBXA2RLMNA | |
| SCHEMBL7210849 | 0.88 | CCR1 (0.63) | CCR1CHRM2CCR5NPC1ALDH1A1 | |
| SCHEMBL7210846 | 0.88 | CCR1 (0.63) | CCR1CHRM2CCR5NPC1ALDH1A1 | |
| SCHEMBL15478347 | 0.87 | CCR1 (0.51) | CCR1CHRM2CCR5TBXA2RNPC1 | |
| SCHEMBL10287606 | 0.85 | CCR1 (0.52) | CCR1CHRM2CCR5TBXA2RNPC1 | |
| SCHEMBL14419991 | 0.85 | CCR1 (0.58) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL13824476 | 0.85 | CCR1 (0.58) | CCR1CHRM2CCR5TBXA2RHRH1 | |
| SCHEMBL12121524 | 0.85 | CCR1 (0.60) | CCR1CHRM2CCR5NPC1ALDH1A1 | |
| SCHEMBL14419988 | 0.85 | CCR1 (0.65) | CCR1CHRM2CCR5TBXA2RNPC1 | |
| SCHEMBL10287614 | 0.84 | CCR1 (0.57) | CCR1CHRM2CCR5TBXA2RHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |