Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.43 |
| ▸ | HRH1 | P35367 | 7/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14420427 | 0.93 | HTR2A (0.40) | HTR2AHRH1SLC6A4HTR2CHTR1D | |
| SCHEMBL14415682 | 0.81 | HTR2A (0.58) | HTR2AHRH1RETDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL5518011 | 0.80 | HTR2A (0.57) | HTR2AHRH1RETDRD2DRD3 | |
| SCHEMBL13867298 | 0.78 | HTR2A (0.63) | HTR2AHRH1RETDRD2DRD3 | |
| SCHEMBL14415683 | 0.72 | HTR2A (0.44) | HTR2AHRH1RETSLC6A4HTR2B | |
| Hydrochloric Acid SCHEMBL5517302 | 0.71 | HTR2A (0.43) | HTR2AHRH1RETSLC6A4HTR2B | |
| SCHEMBL11822622 | 0.71 | PIN1 (0.46) | HTR2ARETHTR2CPRCPPIN1 | |
| SCHEMBL14415680 | 0.69 | HTR2A (0.43) | HTR2AHRH1RETDRD2DRD3 | |
| SCHEMBL5514752 | 0.69 | HTR2A (0.40) | HTR2ASLC6A4HTR2CHTR1DHTR1B | |
| SCHEMBL11722433 | 0.68 | HTR2A (0.63) | HTR2AHRH1RETDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268166-B2 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases | NPS PHARMACEUTICALS, INC. (US) | 2007-09-11 | — | — | US | disclosed |