Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | EIF4E | P06730 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13277399 | 0.89 | CYP11B1 (0.52) | CDK6CYP11B1CYP11B2PIK3CDPIK3CA | |
| SCHEMBL12812023 | 0.88 | HPGD (0.62) | CDK6HPGDERN1ALDH1A1PIK3CD | |
| SCHEMBL1442373 | 0.87 | HPGD (0.46) | CDK6HPGDCYP11B1CYP11B2EGLN1 | |
| SCHEMBL1442624 | 0.84 | HPGD (0.68) | CDK6HPGDALDH1A1KDM4E | |
| SCHEMBL1441709 | 0.83 | HPGD (0.70) | CDK6HPGDALDH1A1KDM4E | |
| SCHEMBL12812039 | 0.83 | HPGD (0.67) | CDK6HPGDALDH1A1MKNK1MKNK2 | |
| SCHEMBL13276453 | 0.79 | CYP11B1 (0.63) | CYP11B1CYP11B2KDM1APIK3CA | |
| SCHEMBL12812391 | 0.77 | HPGD (0.53) | CDK6HPGDEGLN1ALDH1A1PIK3CD | |
| SCHEMBL1444098 | 0.77 | HPGD (0.53) | CDK6HPGDPIK3CDPIK3CAPIK3CB | |
| SCHEMBL1443289 | 0.77 | LRRK2 (0.48) | CDK6HPGDEGLN1ALDH1A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473498-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2012-07-11 | — | — | EP | claimed |
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | claimed |