Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442106 | 0.87 | CDK6 (0.53) | HPGDKDM1ACYP11B1CYP11B2CDK6 | |
| SCHEMBL12812039 | 0.80 | HPGD (0.67) | HPGDCDK6 | |
| SCHEMBL1443171 | 0.78 | MTOR (0.53) | LRRK2PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL12812062 | 0.78 | PIK3CA (0.52) | LRRK2PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL1441709 | 0.77 | HPGD (0.70) | HPGDCDK6 | |
| SCHEMBL13277399 | 0.77 | CYP11B1 (0.52) | CYP11B1CYP11B2CDK6PIK3CAPIK3CB | |
| SCHEMBL13276453 | 0.77 | CYP11B1 (0.63) | KDM1ACYP11B1CYP11B2LRRK2PIK3CA | |
| SCHEMBL1442624 | 0.76 | HPGD (0.68) | HPGDCDK6 | |
| SCHEMBL12812023 | 0.76 | HPGD (0.62) | HPGDCDK6PIK3CAPIK3CBMTOR | |
| SCHEMBL1443923 | 0.74 | HPGD (0.67) | HPGDCDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473498-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2012-07-11 | — | — | EP | claimed |
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | claimed |