SCHEMBL14422017

SCHEMBL14422017

Cc1ncc2c(NC3c4cc(Cl)c(F)c(O)c4[C@H](C)C[C@]3(O)C(F)(F)F)cc(F)cc2n1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 5/20 0.63
PGR P06401 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1260369 1.00 NR3C1 (0.63) NR3C1PGR
SCHEMBL1260370 1.00 NR3C1 (0.63) NR3C1PGR
SCHEMBL1260161 0.90 NR3C1 (0.56) NR3C1PGR
SCHEMBL1261143 0.90 NR3C1 (0.79) NR3C1PGR
SCHEMBL1260160 0.90 NR3C1 (0.56) NR3C1PGR
SCHEMBL1260109 0.89 NR3C1 (0.61) NR3C1PGR
SCHEMBL1260111 0.89 NR3C1 (0.61) NR3C1PGR
SCHEMBL12893344 0.89 NR3C1 (0.61) NR3C1PGR
SCHEMBL1262156 0.89 NR3C1 (0.61) NR3C1PGR
SCHEMBL14422069 0.89 NR3C1 (0.61) NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007104582-A1 TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2007-09-20 WO disclosed