Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.58 |
| ▸ | CDK2 | P24941 | 6/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942086 | 0.85 | LMNA (0.57) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422224 | 0.85 | LMNA (0.60) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422205 | 0.85 | LMNA (0.57) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422223 | 0.85 | LMNA (0.59) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422231 | 0.84 | LMNA (0.56) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422230 | 0.83 | LMNA (0.57) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5215439 | 0.83 | MAPT (0.59) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422225 | 0.82 | LMNA (0.56) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422228 | 0.82 | LMNA (0.56) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14422227 | 0.82 | LMNA (0.56) | CDK5CDK5R1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |