Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422194 | 0.87 | NPC1 (0.50) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422262 | 0.86 | MAPK1 (0.55) | MEN1KMT2AGRM4MAPTLMNA | |
| SCHEMBL14422241 | 0.85 | KDM1A (0.55) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422234 | 0.84 | KMT2A (0.52) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422247 | 0.83 | RAB9A (0.64) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422235 | 0.81 | KMT2A (0.56) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL5215470 | 0.81 | RAB9A (0.50) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422251 | 0.78 | KDM1A (0.56) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422256 | 0.78 | KDM1A (0.47) | MEN1KMT2AKDM1ANPC1RAB9A | |
| SCHEMBL14422240 | 0.75 | NPC1 (0.52) | MEN1KMT2AKDM1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |