Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 8/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 9/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422755 | 0.86 | PIM1 (0.54) | PIM1MALT1CDK2FLT3 | |
| SCHEMBL14422761 | 0.84 | PIM1 (0.65) | PIM1MALT1CDK2FLT3CYP3A4 | |
| SCHEMBL14422795 | 0.84 | PIM1 (0.64) | PIM1MALT1CDK2FLT3CYP3A4 | |
| SCHEMBL14422734 | 0.81 | ABCG2 (0.47) | FLT3 | |
| SCHEMBL14422765 | 0.81 | PIM1 (0.67) | PIM1MALT1CDK2FLT3CYP3A4 | |
| SCHEMBL14422680 | 0.81 | PIM1 (0.71) | PIM1MALT1CDK2FLT3 | |
| SCHEMBL14422759 | 0.75 | PIM1 (0.65) | PIM1MALT1CDK2FLT3 | |
| SCHEMBL14422748 | 0.74 | KDM4E (0.43) | CDK2FLT3CYP2C9CYP2C19 | |
| SCHEMBL14422768 | 0.73 | MALT1 (0.72) | PIM1MALT1CDK2FLT3KCNH2 | |
| SCHEMBL14422769 | 0.73 | PIM1 (0.67) | PIM1MALT1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |