Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 8/20 | 0.64 |
| ▸ | MALT1 | Q9UDY8 | 9/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422761 | 0.87 | PIM1 (0.65) | PIM1MALT1JAK2CDK2FLT3 | |
| SCHEMBL14422759 | 0.85 | PIM1 (0.65) | PIM1MALT1JAK2CDK2FLT3 | |
| SCHEMBL14422765 | 0.84 | PIM1 (0.67) | PIM1MALT1JAK2CDK2FLT3 | |
| SCHEMBL14422752 | 0.84 | PIM1 (0.48) | PIM1MALT1CDK2FLT3CYP3A4 | |
| SCHEMBL14422769 | 0.82 | PIM1 (0.67) | PIM1MALT1MAPTJAK2CDK2 | |
| SCHEMBL14422755 | 0.82 | PIM1 (0.54) | PIM1MALT1JAK2CDK2FLT3 | |
| SCHEMBL14422768 | 0.82 | MALT1 (0.72) | PIM1MALT1JAK2CDK2FLT3 | |
| SCHEMBL14422818 | 0.82 | PIM1 (0.58) | PIM1MALT1POLBMAPTHSD17B10 | |
| SCHEMBL14422763 | 0.82 | PIM1 (0.55) | PIM1MALT1JAK2CDK2FLT3 | |
| SCHEMBL14422770 | 0.79 | PIM1 (0.53) | PIM1MALT1POLBMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |