Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23461138 | 0.89 | F2 (0.51) | F2MAPTMEN1ALDH1A1HTT | |
| SCHEMBL14423553 | 0.89 | F2 (0.69) | F2P2RX3PRSS1PRSS2PRSS3 | |
| SCHEMBL3242816 | 0.79 | F2 (0.57) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23461178 | 0.79 | F2 (0.44) | F2MAPTMEN1ALDH1A1HTT | |
| SCHEMBL7139116 | 0.72 | KDM4E (0.45) | F2MEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL23461146 | 0.70 | F2 (0.48) | F2ALDH1A1HSD17B10TSHRPOLB | |
| SCHEMBL5475869 | 0.70 | F2 (0.39) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3240571 | 0.70 | TPSAB1 (0.43) | F2MEN1ALDH1A1KMT2AP2RX3 | |
| SCHEMBL5474694 | 0.70 | F2 (0.64) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8292993 | 0.69 | F2 (0.47) | F2ALDH1A1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262211-B2 | Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation | DENDREON CORPORATION (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262211-B2 | Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation | DENDREON CORPORATION (US) | 2007-08-28 | — | — | US | disclosed |