TPSAB1

Tryptase beta-1 · Q15661 · TPSAB1 on Sugi Atlas →

31,366 patent compounds predicted against TPSAB1, 15,795 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Trifluoroacetic Acid (SCHEMBL1385077)	1.00	20/20
Trifluoroacetic Acid (SCHEMBL1382133)	0.52	20/20
Trifluoroacetic Acid (SCHEMBL1382520)	0.52	20/20
Trifluoroacetic Acid (SCHEMBL1381412)	0.51	20/20
Trifluoroacetic Acid (SCHEMBL1386521)	0.60	19/20
SCHEMBL1275020	0.51	19/20
Trifluoroacetic Acid (SCHEMBL1382249)	0.51	19/20
Trifluoroacetic Acid (SCHEMBL1381956)	0.50	19/20
SCHEMBL1275893	0.59	18/20
SCHEMBL1274992	0.58	18/20
Hydrochloric Acid (SCHEMBL1275018)	0.57	18/20
SCHEMBL1274978	0.59	17/20
SCHEMBL1275890	0.58	17/20
Trifluoroacetic Acid (SCHEMBL1381804)	0.58	17/20
SCHEMBL1275882	0.51	17/20
SCHEMBL951611	0.58	16/20
Trifluoroacetic Acid (SCHEMBL1382730)	0.54	16/20
Hydrochloric Acid (SCHEMBL1274761)	0.52	16/20
Trifluoroacetic Acid (SCHEMBL1382740)	0.61	15/20
Hydrochloric Acid (SCHEMBL1275313)	0.54	15/20

Clinical trials — most relevant to TPSAB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Imatinib in KIT-negative Systemic Mastocytosis	PHASE4	COMPLETED
Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults	PHASE3	COMPLETED
Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocytosis	PHASE3	COMPLETED
Effects of Anti-TSLP in Patients With Asthma	PHASE2	COMPLETED
The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose	PHASE2	COMPLETED
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	PHASE2	COMPLETED
Evaluation of Response to Use of Intravesical Ozone Gas in Interstitial Cystitis /Bladder Pain Syndrome	PHASE2	UNKNOWN
Zemaira Eosinophilic Esophagitis Pilot Study	PHASE2	RECRUITING
Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)	PHASE1	NOT_YET_RECRUITING
Sumatriptan and Glucose	EARLY_PHASE1	UNKNOWN
Investigation of the Frequency of Hereditary Hyper Alpha-tryptasemia in Patients With Elevated Basal Tryptasemia	nan	ACTIVE_NOT_RECRUITING
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Simultaneous Study of the Serum Tryptase Level of the Mother and the Child During Childbirth (TryPla)	nan	UNKNOWN
Role of Tryptase Levels in Patients With Stable Coronary Artery Disease.	nan	RECRUITING
Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement	nan	UNKNOWN
Genetic Determinism of Epithelial Barrier Defects in Irritable Bowel Syndrome	nan	WITHDRAWN
Dosage of Serum Tryptase Levels in a Population of Premature Newborns to Evaluate Mast Cell Activity	nan	COMPLETED
Persistence of Sensitization to Contrast Media	nan	NOT_YET_RECRUITING
Tryptase and Coronary Heart Disease	nan	COMPLETED
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis	nan	COMPLETED
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing	nan	COMPLETED
Diagnosis and Allergen Identification of Perioperative Anaphylaxis	nan	RECRUITING
Perioperative Anaphylaxis in Patients Attending University Hospitals (Egypt - UK).	nan	COMPLETED
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals	nan	COMPLETED
Cause of Unexplained Anaphylaxis	nan	ACTIVE_NOT_RECRUITING
Prevalence of Allergic Diseases and Atopy in Subjects With Coronary Artery Disease	nan	COMPLETED
Pathogenesis of Physical Induced Urticarial Syndromes	nan	COMPLETED
Serum Basal Tryptase Levels in Healthy Children	nan	COMPLETED
Cause and Natural Course of Pediatric-Onset Mastocytosis	nan	COMPLETED
Allergy and Immunology Natural History Study	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TPSAB1 binder may also engage these)

Protein	Name	Similarity
TPSB2	Tryptase beta-2	1.000	landscape →
P21845	—	1.000	P21845 →
P27435	—	0.996	P27435 →
Q02844	—	0.994	Q02844 →
Q9XSM2	—	0.993	Q9XSM2 →
Q9N2D1	—	0.993	Q9N2D1 →
P50342	—	0.992	P50342 →
P50343	—	0.992	P50343 →
Q99MS4	—	0.986	Q99MS4 →
Q9QYZ9	—	0.986	Q9QYZ9 →
KLK3	Prostate-specific antigen	0.985	landscape →
Q8BJR6	—	0.985	Q8BJR6 →
P09582	—	0.984	P09582 →
A6NIE9	—	0.984	A6NIE9 →
P15944	—	0.984	P15944 →
KLK2	Kallikrein-2	0.983	landscape →
Q9ER10	—	0.983	Q9ER10 →
P83748	—	0.983	P83748 →
KLK13	Kallikrein-13	0.982	landscape →
Q5FBW2	—	0.982	Q5FBW2 →
A1L453	—	0.981	A1L453 →
P32038	—	0.981	P32038 →
Q6BEA2	—	0.980	Q6BEA2 →
P35034	—	0.980	P35034 →
Q9ESD1	—	0.980	Q9ESD1 →
Q28773	—	0.980	Q28773 →
Q07276	—	0.980	Q07276 →
Q9JHJ7	—	0.980	Q9JHJ7 →
Q3V0Q7	—	0.980	Q3V0Q7 →
P33619	—	0.979	P33619 →