Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.44 |
| ▸ | FLT1 | P17948 | 10/20 | 0.44 |
| ▸ | FLT4 | P35916 | 10/20 | 0.44 |
| ▸ | CCR1 | P32246 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896037 | 1.00 | KDR (0.44) | KDRFLT1FLT4CCR1KIT | |
| SCHEMBL1896040 | 1.00 | KDR (0.44) | KDRFLT1FLT4CCR1KIT | |
| SCHEMBL1891779 | 0.92 | KDR (0.53) | KDRFLT1FLT4CCR1KCNH2 | |
| SCHEMBL1895332 | 0.92 | KDR (0.53) | KDRFLT1FLT4CCR1KCNH2 | |
| SCHEMBL1890518 | 0.86 | KDR (0.38) | KDRFLT1FLT4KITPAK1 | |
| SCHEMBL1890519 | 0.86 | KDR (0.38) | KDRFLT1FLT4KITPAK1 | |
| SCHEMBL4714048 | 0.81 | KIT (0.37) | KITMAPK1 | |
| SCHEMBL1893413 | 0.80 | KDR (0.42) | KDRFLT1FLT4CCR1KCNH2 | |
| SCHEMBL1893412 | 0.80 | KDR (0.42) | KDRFLT1FLT4CCR1KCNH2 | |
| SCHEMBL1892317 | 0.80 | KDR (0.61) | KDRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253286-B2 | Urea derivatives containing aromatic or heteroaromatic rings, useful as prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI CO., LTD (JP) | 2007-08-07 | — | — | US | disclosed |
| US-7253286-B2 | Urea derivatives containing aromatic or heteroaromatic rings, useful as prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI CO., LTD (JP) | 2007-08-07 | — | — | US | disclosed |