Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10114758 | 1.00 | SHMT2 (0.39) | SHMT2BRAFKDRSMN1; SMN2MAPT | |
| SCHEMBL10114772 | 0.94 | SHMT2 (0.36) | SHMT2BRAFKDRSMN1; SMN2MAPT | |
| SCHEMBL13204288 | 0.94 | SHMT2 (0.36) | SHMT2BRAFKDRSMN1; SMN2MAPT | |
| SCHEMBL12882326 | 0.89 | MEN1 (0.38) | SMN1; SMN2MAPTMEN1KMT2AGRIA2 | |
| SCHEMBL10114738 | 0.89 | MEN1 (0.38) | SMN1; SMN2MAPTMEN1KMT2AGRIA2 | |
| SCHEMBL10114384 | 0.88 | MAPT (0.48) | BRAFKDRMAPTMEN1KMT2A | |
| SCHEMBL10133387 | 0.88 | MAPT (0.48) | BRAFKDRMAPTMEN1KMT2A | |
| SCHEMBL10115607 | 0.85 | USP2 (0.38) | KMT2ANPC1TSHR | |
| SCHEMBL10134102 | 0.84 | TSHR (0.37) | MAPTGRIA2GSK3BJAK1POLB | |
| SCHEMBL10114730 | 0.84 | TSHR (0.37) | MAPTGRIA2GSK3BJAK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |