Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | IL1RN | P18510 | 1/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | PHGDH | O43175 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889311 | 0.91 | IKBKB (0.67) | HTR6IKBKBALDH1A1PHGDHPOLB | |
| SCHEMBL4064536 | 0.90 | HTR6 (0.68) | HTR6IKBKBALDH1A1IL1RNKEAP1 | |
| SCHEMBL6973491 | 0.86 | IKBKB (0.69) | HTR6IKBKBALDH1A1MEN1KMT2A | |
| SCHEMBL2889176 | 0.86 | IKBKB (0.69) | HTR6IKBKBALDH1A1PKMPHGDH | |
| SCHEMBL246188 | 0.84 | HTR6 (0.72) | HTR6IKBKBALDH1A1IL1RNKEAP1 | |
| SCHEMBL27482732 | 0.84 | HTR6 (0.72) | HTR6IKBKBALDH1A1IL1RNKEAP1 | |
| SCHEMBL1690514 | 0.84 | HTR6 (0.72) | HTR6ALDH1A1IL1RNKEAP1ERAP1 | |
| SCHEMBL13028510 | 0.83 | IKBKB (0.64) | HTR6IKBKBALDH1A1MEN1KMT2A | |
| SCHEMBL13028493 | 0.83 | IKBKB (0.64) | HTR6IKBKBALDH1A1PHGDHSMN1; SMN2 | |
| SCHEMBL2891992 | 0.83 | IKBKB (0.68) | HTR6IKBKBALDH1A1MEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39850-E1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2007-09-18 | — | — | US | disclosed |