SCHEMBL14428889

SCHEMBL14428889

CNCCC1(O)CCc2cc(F)ccc2C1C(C)C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 11/20 0.51
CYP2D6 P10635 12/20 0.40
CACNA1H O95180 4/20 0.37
CACNA1C Q13936 2/20 0.37
MAPT P10636 3/20 0.36
CACNA1B Q00975 3/20 0.36
MEN1 O00255 2/20 0.36
ALDH1A1 P00352 2/20 0.36
KMT2A Q03164 2/20 0.36
SLC6A2 P23975 3/20 0.35
SLC6A4 P31645 3/20 0.35
SLC6A3 Q01959 2/20 0.35
KCNH2 Q12809 2/20 0.35
ABCB11 O95342 2/20 0.35
NPC1 O15118 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNA1F O60840 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
CHRM2 P08172 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22761556 1.00 CYP3A4 (0.51) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL22761498 1.00 CYP3A4 (0.51) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL2259283 1.00 CYP3A4 (0.51) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL22734745 1.00 CYP3A4 (0.51) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL22734707 0.88 CYP3A4 (0.49) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL22761552 0.88 CYP3A4 (0.49) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL9737738 0.86 CYP3A4 (0.53) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL2259508 0.86 CYP3A4 (0.53) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
SCHEMBL8709648 0.86 CYP3A4 (0.53) CYP3A4CYP2D6CACNA1HCACNA1CMAPT
Hydrochloric Acid SCHEMBL10798620 0.82 CYP3A4 (0.49) CYP3A4CYP2D6CACNA1HCACNA1CMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7265142-B2 Materials and methods for the treatment of hypertension and angina ARYX THERAPEUTICS (US) 2007-09-04 US disclosed