SCHEMBL14429166

SCHEMBL14429166

[N-]=[N+]=Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1CO

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.56
HIF1A Q16665 1/20 0.56
ADORA3 P0DMS8 3/20 0.54
ADORA1 P30542 2/20 0.54
SLC29A1 Q99808 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
DPP4 P27487 1/20 0.54
MEN1 O00255 1/20 0.54
SLC28A1 O00337 1/20 0.54
MAP3K7 O43318 1/20 0.54
SLC28A2 O43868 1/20 0.54
GAPDH P04406 1/20 0.54
MAPK1 P28482 1/20 0.54
ADORA2A P29274 1/20 0.54
ADORA2B P29275 1/20 0.54
STAT6 P42226 1/20 0.54
PI4KA P42356 1/20 0.54
KMT2A Q03164 1/20 0.54
PI4K2B Q8TCG2 1/20 0.54
DOT1L Q8TEK3 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30274492 0.92 ADORA3 (0.65) ALDH1A1HIF1AADORA3ADORA1SLC29A1
SCHEMBL23928736 0.92 ADORA3 (0.65) ALDH1A1HIF1AADORA3ADORA1SLC29A1
SCHEMBL14429167 0.81 ADORA3 (0.82) ALDH1A1HIF1AADORA3ADORA1SLC29A1
SCHEMBL14429168 0.79 ADORA2A (0.48) ALDH1A1HIF1AADORA3ADORA1SLC29A1
SCHEMBL1054240 0.77 SLC29A1 (0.69) ALDH1A1ADORA3ADORA1SLC29A1SMN1; SMN2
SCHEMBL1054238 0.77 SLC29A1 (0.69) ALDH1A1ADORA3ADORA1SLC29A1SMN1; SMN2
SCHEMBL17772332 0.77 SLC29A1 (0.69) ALDH1A1ADORA3ADORA1SLC29A1SMN1; SMN2
SCHEMBL21011214 0.77 HIF1A (0.64) HIF1ASMN1; SMN2LMNATP53HTT
SCHEMBL25752695 0.77 HIF1A (0.64) HIF1ASMN1; SMN2LMNATP53HTT
SCHEMBL28747306 0.77 SLC29A1 (0.65) ADORA3ADORA1SLC29A1SMN1; SMN2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070185063-A1 Seven-membered ring nucleosides IDENIX PHARMACEUTICALS, INC. 2007-08-09 US disclosed
US-20070185063-A1 Seven-membered ring nucleosides IDENIX PHARMACEUTICALS, INC. 2007-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070185063-A1 Seven-membered ring nucleosides NSUN2, NSUN3, HAVCR2 ALDH1A1 2563/4885HIF1A 3398/4885ADORA3 332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.