SCHEMBL14429381

SCHEMBL14429381

C[C@H](Cc1cccc(CCC(=O)NC2Cc3ccccc3C2)c1)NC[C@H](CC(C)(C)[Si](C)(C)O)c1ccc(O)c(CO)c1

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 20/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14429565 0.94 ADRB2 (0.53) ADRB2
SCHEMBL14429290 0.86 ADRB2 (0.51) ADRB2
SCHEMBL4255086 0.85 ADRB2 (0.63) ADRB2
SCHEMBL4255082 0.85 ADRB2 (0.63) ADRB2
SCHEMBL13590887 0.85 ADRB2 (0.53) ADRB2
SCHEMBL13590886 0.85 ADRB2 (0.53) ADRB2
SCHEMBL4258485 0.84 ADRB2 (0.46) ADRB2
SCHEMBL4258482 0.84 ADRB2 (0.46) ADRB2
SCHEMBL14430026 0.84 ADRB2 (0.47) ADRB2
SCHEMBL13590827 0.84 ADRB2 (0.52) ADRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7268147-B2 Compounds useful for the treatment of diseases PFIZER INC (US) 2007-09-11 US disclosed