Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13062776 | 0.88 | PDE3B (0.46) | PDE3BPDE3AMAOAMAOBKCNH2 | |
| SCHEMBL1267822 | 0.82 | PDE3B (0.46) | PDE3BPDE3AMAOAMAOBKCNH2 | |
| SCHEMBL13356413 | 0.82 | PDE3B (0.43) | PDE3BPDE3AMAOAMAOBKCNH2 | |
| SCHEMBL5438754 | 0.81 | KCNH2 (0.43) | PDE3BPDE3AKCNH2 | |
| SCHEMBL5747413 | 0.80 | PDE3B (0.41) | PDE3BPDE3AMAOAMAOBKCNH2 | |
| SCHEMBL4142652 | 0.76 | PDE3B (0.52) | PDE3BPDE3AMAOAMAOBEPHX2 | |
| SCHEMBL25060982 | 0.74 | PDE3B (0.40) | PDE3BPDE3AKCNH2LMNA | |
| SCHEMBL4142650 | 0.73 | PDE3B (0.46) | PDE3BPDE3AMAOAMAOBEPHX2 | |
| SCHEMBL30047289 | 0.73 | PDE3B (0.46) | PDE3BPDE3AMAOAMAOBEPHX2 | |
| SCHEMBL2292992 | 0.73 | PDE3B (0.46) | PDE3BPDE3AMAOAMAOBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007086016-A1 | TETRAHYDROPYRANE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-08-02 | — | — | WO | disclosed |