Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14311506 | 0.86 | ALDH1A1 (0.64) | ALDH1A1LMNAMEN1KMT2AALDH3A1 | |
| SCHEMBL12123780 | 0.86 | ALDH1A1 (0.69) | L3MBTL1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL8053456 | 0.85 | ALDH1A1 (0.67) | ALDH1A1LMNAMEN1KMT2AALDH3A1 | |
| Hydrochloric Acid SCHEMBL7934870 | 0.85 | ALDH1A1 (0.70) | L3MBTL1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL2955689 | 0.82 | ALDH1A1 (0.72) | ALDH1A1MAPTLMNAHSD17B10HTT | |
| SCHEMBL14431659 | 0.82 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL12947818 | 0.81 | KMT2A (0.69) | L3MBTL1ALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL3159167 | 0.81 | ALDH1A1 (0.71) | ALDH1A1MAPTLMNAHSD17B10HTT | |
| SCHEMBL13492106 | 0.78 | ALDH1A1 (0.56) | L3MBTL1ALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL27290057 | 0.77 | HSD17B10 (0.57) | L3MBTL1ALDH1A1MAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490371-B1 | THIOPHENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL MYERS SQUIBB CO (US) | 2007-08-15 | — | — | EP | disclosed |