Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.43 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948957 | 0.85 | KDM4E (0.48) | GPR119KDM4EPKMSTSMEN1 | |
| SCHEMBL948117 | 0.81 | GPR119 (0.49) | GPR119KDM4EPKMPRMT5WDR77 | |
| SCHEMBL14433203 | 0.80 | GPR119 (0.46) | GPR119KDM4EPKMPRMT5WDR77 | |
| SCHEMBL948590 | 0.78 | GPR119 (0.45) | GPR119KDM4EPKMSTSMEN1 | |
| SCHEMBL948589 | 0.78 | GPR119 (0.45) | GPR119KDM4EPKMSTSMEN1 | |
| SCHEMBL3249107 | 0.77 | STS (0.58) | GPR119KDM4EPKMPRMT5WDR77 | |
| SCHEMBL16804450 | 0.75 | GPR119 (0.49) | GPR119KDM4EPKMPRMT5WDR77 | |
| SCHEMBL949394 | 0.74 | KDM4E (0.45) | GPR119KDM4EPKMSTSMEN1 | |
| SCHEMBL19839715 | 0.74 | GPR119 (0.56) | GPR119KDM4EPKMPRMT5WDR77 | |
| SCHEMBL23293089 | 0.74 | GPR119 (0.52) | GPR119KDM4EPKMPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185163-A1 | Imidazol derivatives of piperidine as histamine antagonists | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185163-A1 | Imidazol derivatives of piperidine as histamine antagonists | HRH2, HRH1, HRH4 | GPR119 179/4885KDM4E 1228/4885PKM 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.